Test for the quantitative determination of GOT
(AST; ASAT; EC 126.96.36.199) in blood, serum or plasma
Glutamate oxaloacetate transaminase (aspartate aminotransferase) belongs to the
group of transaminases which catalyze the conversion of amino acids to the corresponding
a-keto acids and vice versa by transfer of amino groups. Aspartate aminotransferase
is found in many tissues of the body. Although high concentrations are present in the
myocardium, significant activities also occur in the brain, the liver, the gastrointestinal
system, the fatty tissue, the skeletal muscle and the kidneys.
GOT is present both in the cytoplasm and in the mitochondria of the cells. After less
severe cell damage the majority of the GOT comes from the cytoplasm and only a small
fraction from the mitochondria. Severe damage releases more mitochondrial enzyme.
Elevated levels of transaminases can indicate myocardial infarction, liver disease,
muscular dystrophy and organ damage.
Available in a tube of 30 test/strips.